Compensatory hyperinsulinemia damages vascular endothelium and is conducive to lipid deposition, thus leading to the occurrence and development of atherosclerosis (2); Obesity and chronic inflammation: fat metabolites are released into the blood of obese patients, resulting in the accumulation of lipid metabolites, the penetration and activation of macrophages, and the chronic inflammatory state of the body, decreased adiponectin levels and increased interleukin-6 and plasminogen activator inhibitors, resulting in a state of high inflammation and high thrombosis. The gene discussed is ADIPOQ; the disease is atherosclerosis.