Furthermore, while CAR-T cells targeting GC-C in colorectal cancer may be promising due to the gut-specificity of GC-C expression and its universal expression in primary tumors and distant metastases, these approaches may also be promising in targeting tumors arising from intestinal metaplasia, such as esophageal, gastric, and pancreatic cancers with ectopic GC-C expression (99, 102, 103). Here, GUCY2C is linked to familial pancreatic carcinoma.