The increase in GC-C expression, ST binding, and ST-stimulated cGMP accumulation in primary cultures of rat hepatocytes and a rat hepatoma cell line (H-35) after treatment with dexamethasone, alone or in combination with interleukin-6 (IL-6), all support the role of GC-C in the regulation of acute hepatic phase response (152). Here, IL6 is linked to hepatocellular carcinoma.