The definition of LADA is usually based on three criteria that were proposed by the Immunology of Diabetes Society (13); 1) presence of autoantibodies, typically GADA, which is a basic criterion that distinguishes LADA from type 2 diabetes; 2) adult onset, often defined as 30 years or older; and 3) lack of insulin treatment during at least 6 months following diagnosis to indicate a slow “latent” progression of autoimmunity and separate LADA from type 1 diabetes. This evidence concerns the gene INS and diabetes mellitus.