In addition, LADA is linked to type 1 diabetes-associated loci outside of the HLA region, including PTPN22, INS, and SH2B3 and the associations with PTPN22 and INS appear stronger for LADA with high GADA and for LADA characterized by multiple autoantibodies, respectively (6). This evidence concerns the gene INS and type 1 diabetes mellitus.