We report a patient initially diagnosed with an HGBL‐TH, in which further morphologic, immunohistochemical, and next‐generation sequencing (NGS) studies of subsequent specimens disclosed it to be a germinal center diffuse large B cell lymphoma (GC‐DLBCL) with BCL2/BCL6 gene translocations, PVT1‐deletion, and gain of MYC genes evolving from a previous follicular lymphoma (FL). Here, BCL6 is linked to diffuse large B-cell lymphoma.