CHEK2 (q = 0.087 in LUSC, q = 0.052 in BLCA) played an important role in the repair of DNA damage, and its heterozygous mutations had been found to be causing genetic susceptibility to lung cancer (Wang et al., 2014) and bladder cancer (Złowocka et al., 2008). Here, CHEK2 is linked to urinary bladder carcinoma.