NF1 p.L43L mutation in TCGA-39-5040 had an over-expressing mutant allele (DNA VAF: 0.32, RNA VAF: 0.63) and showed an upregulated gene expression (tumor/paired-normal fold change: 2.53), which activated NF1 function to under-regulate the RAS signaling pathway and suppressed carcinogenesis. This evidence concerns the gene NF1 and neoplasm.