This study generated a signature featuring 12 FAM-related genes (ADPRHL1, DYNC1I1, KCNG1, LINC00460, EPHX3, SPINK7, FCRLA, MASP1, ZNF541, CD5, BEST2, ZAP70) and found that it could predict survival in patients with HNSCC. Here, BEST2 is linked to head and neck squamous cell carcinoma.