This study generated a signature featuring 12 FAM-related genes (ADPRHL1, DYNC1I1, KCNG1, LINC00460, EPHX3, SPINK7, FCRLA, MASP1, ZNF541, CD5, BEST2, ZAP70) and found that it could predict survival in patients with HNSCC. The gene discussed is LINC00460; the disease is head and neck squamous cell carcinoma.