Zhang et al. (2020) found that miR-449a downregulated the expression of ATG4B by binding to the 3′UTR of its mRNA, which subsequently reduced the autophagy of T-cell lymphoma cells and promoted tumor apoptosis. Li et al. (2019) showed that CUL4B activated the protective autophagy to promote the growth of DLBCL cells through the JNK signaling pathway, and interfering with the expression of CUL4B could inhibit autophagy by regulating the JNK signaling pathway, thereby decreasing cell proliferation. The gene discussed is CUL4B; the disease is diffuse large B-cell lymphoma.