Xu et al. (2021)uncovered that ARRDC1-AS1 facilitated the progression of DLBCL and enhanced autophagy of DLBCL by targeting the miR-2355-5p/ATG5 axis. Additionally, Amaravadi et al. (2007)found that inhibition of autophagy with either chloroquine or ATG5 short hairpin RNA (shRNA) enhanced the ability of either p53 activation or alkylating drug therapy to induce lymphoma cell death. Here, TP53 is linked to diffuse large B-cell lymphoma.