Further experiments showed that upregulation of CPNE7, a calcium-dependent phospholipid -binding protein in tumor-derived MSCs, promotes phosphorylation of p65 and IκBα as well as nuclear translocation of p65, which activates the NF-κB pathway, promotes the expression of IL-8, and thus promotes tumor metastasis. The gene discussed is CXCL8; the disease is neoplasm.