Tumor-secreted cytokines and growth factors, such as PDGF-AB, VEGF, hepatocyte growth factor, IL-8, etc., can recruit local and distant MSCs, and MSCs can also influence tumor progression by affecting angiogenesis, regulating immunity, inducing apoptosis, inhibiting or promoting proliferation, invasion, migration, etc. As mentioned above, MSCs from different tissues have different effects on oral tumors, including those from normal, precancerous and cancerous tissues, which provide a new perspective for further exploration of oral cancer progression and treatment. This evidence concerns the gene HGF and lip and oral cavity carcinoma.