Dental pulp stem cells (DPSCs)-derived CM induced apoptosis in tumor cells, inhibited the proliferation of TSCC cells AW13516 by enhancing the expression of p16, enhanced the invasion, adhesion, and multidrug resistance of AW13516 by upregulating angiopoietin-2, epidermal growth factor, macrophage-stimulating factor, PDGF-AA, PDGF-BB, TNF-α, and IL-2, downregulating the anti-inflammatory cytokines TNF-β1, and pro-inflammatory cytokine IL-4 (Raj et al., 2021a). This evidence concerns the gene TNF and neoplasm.