Furthermore, we selected 11 interacting genes including CCL16, CCR9, CHST4, CXCL3. IFNG, IL6, MS4A1, POU2AF1, SPTA1, TNFSF9, and TREM1 from the humoral immune response (GO: 0006959), immune response (GO: 0006955), and positive regulation of T-cell proliferation (GO: 0042102)Among 11 interacting genes associated with the immune response, Kaplan–Meier analysis indicated the high expression of SPTA1 was related to a better prognosis of neuroblastoma patients (Figure 8C). This evidence concerns the gene POU2AF1 and neuroblastoma.