It promoted cell proliferation, invasion and migration in head and neck squamous cell carcinoma and melanoma cells (Atkinson et al., 2019; Wang et al., 2020) and reduced the anti-tumor activity of COL6A6 on growth and metastasis of AtT-20 and HP75 melanoma cells due to an action on PI3K-Akt signaling (Long et al., 2019). This evidence concerns the gene COL6A6 and neoplasm.