CTLA4 and nonpapillary renal cell carcinoma: In order to predict the effect of drug treatment in patients with different subtypes, we constructed the immunophenogram for forecasting anti- PD-1 therapy sensitivity of ccRCC, which presented that C3 patients were in an activated state of pyroptosis and were sensitive to anti-PD-1 therapy and a combination of anti-CTLA4 and anti-PD-1 therapy.