NFE2L3 and cancer: Furthermore, NFE2L3 expression was significantly upregulated in paired cancer and adjacent samples of 16 cancer types, including BLCA, BRCA, CHOL, COAD, ESCA, HNSC, KIRC, KIRP, LIHC, LUAD, LUSC, PRAD, READ, STAD, THCA, and UCEC (Figure 1D).