A heatmap was constructed in order to show the differentially expressed PRGs between the normal and tumor samples (Figure 1A), of which a total of 15 PRGs were found to be differentially expressed in normal and tumor samples, while 11 genes (AIM2, GPX4, NLRP7, NLRP2, CASP3, CASP5, CASP6, CASP8, PYCARD, PLCG1, and GSDMD) were upregulated and four genes (IL6, NLRP3, ELANE, and NLRP1) were downregulated in the BC samples. The gene discussed is CASP8; the disease is breast cancer.