IDH1 and neoplasm: Figure 6D shows the distribution of the 15 most frequently mutated genes in LGG, including IDH1, in the high- and low-risk groups. We also calculated the tumor mutation burden (TMB) for each LGG patient based on the mutation dataset of the TCGA cohort and found a significant positive correlation between TMB and risk score (Figure 6E). Additionally, the high-risk score group had significantly higher HRD scores than the low-risk score group (p < 0.05, Figure 6F).