This risk model had the largest C-index (C-index = 0.873) and contained 11 key HRD-related genes (KCNK3, ASPM, HOXD4, SLC7A14, OSR2, ZNF560, IRX5, ATP8A2, SPOCD1, FOXE1, and CHST9), of which four were favorable prognostic factors for LGG and seven were unfavorable prognostic factors (Figure 2C). Here, HOXD4 is linked to hypoparathyroidism-retardation-dysmorphism syndrome.