IRX5 and hypoparathyroidism-retardation-dysmorphism syndrome: This risk model had the largest C-index (C-index = 0.873) and contained 11 key HRD-related genes (KCNK3, ASPM, HOXD4, SLC7A14, OSR2, ZNF560, IRX5, ATP8A2, SPOCD1, FOXE1, and CHST9), of which four were favorable prognostic factors for LGG and seven were unfavorable prognostic factors (Figure 2C).