This risk model had the largest C-index (C-index = 0.873) and contained 11 key HRD-related genes (KCNK3, ASPM, HOXD4, SLC7A14, OSR2, ZNF560, IRX5, ATP8A2, SPOCD1, FOXE1, and CHST9), of which four were favorable prognostic factors for LGG and seven were unfavorable prognostic factors (Figure 2C). This evidence concerns the gene ASPM and hypoparathyroidism-retardation-dysmorphism syndrome.