Matsunaga et al. (2021) found that the downregulation of ATP8A2 in C6 glioma cells cultured under serum-free conditions inhibited the stress-induced externalization of annexin A2 and ablated membrane lipid asymmetry. A study by Liu et al. (2018) revealed that SPOCD1 promotes proliferation and metastasis of glioma cells by upregulating the expression of Pentraxin 3. The gene discussed is ANXA2; the disease is central nervous system cancer.