Matsunaga et al. (2021) found that the downregulation of ATP8A2 in C6 glioma cells cultured under serum-free conditions inhibited the stress-induced externalization of annexin A2 and ablated membrane lipid asymmetry. A study by Liu et al. (2018) revealed that SPOCD1 promotes proliferation and metastasis of glioma cells by upregulating the expression of Pentraxin 3. Here, ATP8A2 is linked to central nervous system cancer.