These genes include SLC12A3 encoding thiazide-sensitive NCC, TRMP6 encoding apical TRPM6 channel, HNF1B encoding HNF1β, PCBD1 encoding PCBD1, EGF encoding EGF, EGFR encoding EGFR, KCNJ10 encoding Kir4.1 (EAST syndrome), KCNA1 encoding Kv1.1, FXYD2 encoding γ-subunit of Na+-K+ ATPase, and CNNM2 encoding CNNM2 (cyclin M2) (Meij et al., 2003; Groenestege et al., 2007; Adalat et al., 2009; Glaudemans et al., 2009; Reichold et al., 2010; de Baaij et al., 2012; Ferrè et al., 2014; Sponder et al., 2016; Chen et al., 2021). This evidence concerns the gene EGF and EAST syndrome.