Selinexor is an oral selective inhibitor of nuclear export (SINE) compound that binds covalently to and inactivates XPO1, leading to the accumulation of TSPs in the nucleus, reducing translation of oncoproteins, enhancing glucocorticoid receptor signaling, and inducing cell cycle arrest, ultimately resulting in death of MM (and other malignant) cells but not in normal cells [15, 16, 17, 18, 19]. The gene discussed is XPO1; the disease is Miyoshi myopathy.