JAK3 and neoplasm: The patient was enrolled in the Molecularly Aided Stratification for Tumor Eradication Research (MASTER) program [2], where a whole genome and transcriptome sequencing performed on the skin biopsy identified several molecular alterations among which there were two heterozygous Janus kinase 3 (JAK3) mutations: A573V (variant allele frequency (VAF) 53%) and M511I (VAF, 56%).