The effects of ONC‐212 on expression of CIpP and TRAIL were more variable but in three of the four samples (CLL #’s 16, 15 and 10), increased expression of CIpP and decreased expression of TRAIL were observed following treatment with at least one dose of ONC‐212. The gene discussed is TNFSF10; the disease is B-cell chronic lymphocytic leukemia.