Our data showing that increased ATF4 expression is inversely associated with expression of BCL2, MCL1 and BCLxL (Figures 3 and 4 and Figure S2A) support the notion that increased ATF4 expression is associated with a pro‐apoptotic shift in expression of the BCL2‐family proteins in CLL cells and increased cell death (Figure 1A). This evidence concerns the gene BCL2 and B-cell chronic lymphocytic leukemia.