SOX2 and central nervous system cancer: The introduction of miR-124 and miR-145 mimetics using mesenchymal stem cells into glioma cells that express very low levels of these microRNAs has shown successful delivery of drugs into cells, where they significantly reduced the luciferase activity of the corresponding target genes miR-124 and miR −145 - SCP-1 and Sox2, and also inhibited glioma cell migration and glioma CSC self-renewal [52].