On a glioma cell line and a laboratory mouse model, the ability of such a microRNA sponge to inhibit miR-23b, which functions as an oncogene in glioblastoma, was demonstrated, which led to a significant decrease in the level of HIF1a, b-catenin, MMP-2, -9, VEGF, inhibited angiogenesis, migration, and invasion of tumor cells [47]. This evidence concerns the gene VEGFA and central nervous system cancer.