In addition, lower CD20 MFI was significantly associated with worse OS for B‐ALL patients who had Ph‐negativity, ≥2 gene mutations, CR in 4 weeks, baseline hemoglobin (Hb) <90 g/L, baseline PLT <100 × 109/L, and MRD positivity within 3 months (all p‐values < 0.05). The gene discussed is GSTM1; the disease is acute lymphoblastic leukemia.