The aim of our study is to evaluate GDF‐15 serum levels and CIMT (as a biomarker for subclinical atherosclerosis) in a cohort of transfusion‐dependent beta‐thalassemic adults to explore their possible correlations with clinical, hematological, and laboratory variables and to reveal the association between risk factors and atherosclerosis. The gene discussed is GDF15; the disease is atherosclerosis.