It was performed on a number of predictors including age, sex, BMI, smoking, history of premature CAD, hypertension, hemoglobin level, ferritin, transferrin saturation, insulin resistance (HOMA‐IR score), lipid profile (cholesterol, triglycerides, LDL, and HDL), hs CRP, history of splenectomy, dependency on blood transfusion, regular ICA therapy, and GDF‐15 level. This evidence concerns the gene TF and Insulin resistance.