WT, wild type; Aldo/salt, aldosterone/salt treatment; ERα, estrogen receptor alpha; ERβ, estrogen receptor beta; F, female; M, male; OPN, osteopontin; MI, myocardial infarction; LV, left ventricle; p-JKN, phosphorylated c-Jun N-terminal kinase; DOC/salt, deoxycorticosterone/salt; mTOR-I, mammalian target of rapamycin inhibition; MR, mineralocorticoid receptor; NO, nitric oxide; I/R, ischemia/reperfusion; KO, knockout; ↑, increase; ↓, decrease; = , equal; +, activation; -, inhibition. The gene discussed is ESR1; the disease is myocardial infarction.