The cardiomyocyte MR knockout mouse (myo-MRKO) has demonstrated a range of novel and important actions of the MR in the regulation of the tissue response to cardiac ischemia including promoting an appropriate wound healing response in the infarct zone, enhanced neovascularization of the scar and maintenance of the microvascular capillary network, which together support cardiac functional recovery and long term viability (Fraccarollo et al., 2011). This evidence concerns the gene NR3C2 and myocardial ischemia.