In agreement, acyl-ghrelin is not detected in GOAT null mice (Gutierrez et al., 2008) and the inhibition of GOAT leads to a decreased presence of acyl-ghrelin in insulinoma cells (Yang et al., 2008a), HEK and HeLa cells (Barnett et al., 2010) as well as in mouse serum (Yang et al., 2008a). This evidence concerns the gene MBOAT4 and pancreatic insulinoma.