A study using myocardial ischemia-reperfusion mice model showed that irisin treatment significantly increased activity of antioxidant factors such as SOD-1 and p38 and markedly reduces of myocardial infarct size (Wang et al., 2017) Moreover, irisin overexpression or irisin treatment exhibited cardioprotective effect by inhibiting ROS and upregulating expression of antioxidant molecules such as GSH and total SOD in acute and chronic cardiotoxicity models. This evidence concerns the gene FNDC5 and myocardial infarction.