Curiously, inappropriate sympathetic activation was shown to potentially upregulate IL-6 levels and vagal stimulation was suggested as a possible tool to reduce systemic inflammation, in a different pathological population characterized by increased sympathetic modulation—a “positive loop” that hence may also provide a potential novel treatment pathway in COPD (Diedrich et al., 2021). The gene discussed is IL6; the disease is chronic obstructive pulmonary disease.