However, MDC, IGFBP4, IGFBP3, MIF, RANTES, TARC, BDNF, NAP-2, TIMP-1, MCP-2, TGF-β1, and TNF-α were significantly different between the lung cancer preradiotherapy and postradiotherapy groups. The gene discussed is IGFBP3; the disease is lung carcinoma.