The results revealed that serum miR-4299 was negatively correlated with Scr (P < 0.0001), Cys-C (P < 0.0001), and KIM-1 (P < 0.0001) and serum miR-16-5p was also negatively associated with them (P < 0.0001, P < 0.0001, and P < 0.0001) (Figure 3), suggesting that the down-regulation of serum miR-4299 and miR-16-5p might be the causes of sepsis complicated with AKI. The gene discussed is HAVCR1; the disease is acute kidney injury.