It is also required to investigate the effect of Plin2 in association with ISCs activation using transgenic models to elucidate this process in diabetes pathogenesis; future studies should also determine whether accumulation in ISCs affects lipid homeostasis in islets and the insulin-resistant state in other tissues; what's more important is when and how the link and signals crosstalk are changed between ISCs and islet cells may answer how changes of LDs levels in ISCs regulate islet cell frangibility to lipotoxicity. Here, INS is linked to diabetes mellitus.