Interestingly, Zhu et al. validated that miR-497-5p targeted the 3′ untranslated region (3′UTR) of PD-L1 mRNA for degradation in clear renal cell carcinoma (CRCC) cells [31], which rendered the possibility that lncRNA FGD5-AS1 might regulate PD-L1 through miR-497-5p in CC cells. This evidence concerns the gene FGD5 and clear cell renal carcinoma.