Recently, targeting lncRNAs-miRNAs-mRNAs ceRNA networks proved to be an effective strategy to slow down the development of multiple cancers [35], and the present study identified a novel lncRNA FGD5-AS1/miR-497-5p/PD-L1 axis that played an important role in regulating colon cancer (CC) progression. Here, FGD5 is linked to malignant colon neoplasm.