The results of HE staining, TTC staining, and TUNEL assay showed that downregulation of lncRNA93358 expression significantly improved the myocardial pathological morphology of MI rats, reduced the myocardial infarction area and myocardial cell apoptosis rate, downregulated Bax, and upregulated Bcl-2. This evidence concerns the gene BCL2 and myocardial infarction.