Next, the overexpression of miR-100-5p reduced IL-1β and IL-1α levels, inhibited MDA and ROS production levels, and increased SOD, CAT, and GSH-px levels in the in vitro model of premature ovarian failure by HUCMSCs, as shown in Figures 5(a)–5(j). This evidence concerns the gene IL1A and primary ovarian failure.