HIV-associated cryptococcal meningitis continues to have a high mortality rate despite widespread availability and use of HAART.<h4>Case</h4>36-year-old male with a past medical history of AIDS and a CD4 count of 35 cells/mm3 presented with altered mental status initially thought to be related to using crystalline methamphetamine as reported by EMS. This evidence concerns the gene CD4 and Cryptococcal meningitis.