However, in the multivariate analysis, only age (HR, 1.010; 95% CI, 1.002–1.017; p = 0.008), pathological T stage (T3–4) (HR, 1.590; 95% CI, 1.208–2.093; p = 0.001), high N stage (p < 0.001), distant metastasis (HR, 3.361; 95% CI, 2.615–4.319; p < 0.001), vascular invasion (HR, 1.419; 95% CI, 1.106–1.821; p = 0.006) and high GNRI-CEA score (p < 0.001) were independent risk factors for PFS in CRC patients (Supplementary Table 4). The gene discussed is CEACAM5; the disease is colorectal carcinoma.