Previous studies have shown that the biophysical properties of channelopathy-causing variants, such as SCN1A (Berecki et al., 2019), KCNA2 (Syrbe et al., 2015), KCNQ2 (Miceli et al., 2015), and GluN2B (Platzer et al., 2017) may correlate with phenotypes. The gene discussed is SCN1A; the disease is channelopathy.