GRIN2B and channelopathy: Previous studies have shown that the biophysical properties of channelopathy-causing variants, such as SCN1A (Berecki et al., 2019), KCNA2 (Syrbe et al., 2015), KCNQ2 (Miceli et al., 2015), and GluN2B (Platzer et al., 2017) may correlate with phenotypes.