AKT1 and myocardial ischemia: We also demonstrated that SYDC reduces myocardial infarct size [6], promotes endothelial function [7], inhibits oxidative injury [8], and protects against myocardial ischemia/reperfusion (I/R) injury in both in vivo and in vitro models via activation of the phosphatidylinositol 3-kinase/Akt (PI3K/Akt) pathway [9].