PTEN and neoplasm: In the tumor microenvironment, oncogenic drivers such as β-catenin, STAT3, PI3K/PTEN/AKT/mTOR, p53, NF-kB, and RAS/RAF/MAPK are activated to suppress the production of chemokines, reduce the recruitment of dendritic cells, macrophages, T cells, and NK cells to tumor sites, and to suppress the immune system of these immunocytes [90].