Rutin decreased blood glucose in db/db mice, inhibited hepatic lipid accumulation, and improved glucose and lipid metabolism disorders; these pharmacological effects may be related to the promotion of the mRNA expression of the adipocyte thermogenic genes MCT1, MCT1, ACSM3, CPT-1α, and CPT-1β, activation of BAT and induction of browning of IWAT, and increasing the concentration of SCFA-producing enzymes, promoting the production of SCFA [19]. The gene discussed is ACSM3; the disease is Disorder of lipid metabolism.