Monocytes proliferate, differentiate into macrophages, and take up lipoproteins to form cholesterol-rich “foam cells.” Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) mediates the recognition and internalization of oxLDL, acting on multiple cells, such as endothelial cells, macrophages, platelets, fibroblasts, and smooth muscle cells; it plays a central role in atherosclerosis [8]. The gene discussed is OLR1; the disease is atherosclerosis.