Through constructing PPI network of PH-WLZ and CHD, common targets, AKT1, CASP3, CCL2, CXCL8, INS, JUN, MMP9, PTGS2, SERPINE1, and TNF found to be the hub genes of PH-WLZ in the treatment of CHD. This evidence concerns the gene SERPINE1 and coronary artery disorder.