Studies have confirmed that activated c-Jun/AP-1 signalling can promote the proliferation and migration of vascular smooth muscle cells, while in atherogenic apolipoprotein E-deficient (ApoE−/−) C57BL/6 mice with high fat in a dietary atherosclerosis model, interference with TRIM7 can effectively alleviate atherosclerosis in vivo by inactivating the c-Jun/AP-1 signalling pathway [19]. The gene discussed is APOE; the disease is atherosclerosis.