Overall, our work is the first to discover the critical importance of CF modification in lung interstitial fibrosis, and GA intervened in EMT to attenuate pulmonary interstitial fibrosis by regulating the key receptor protein TGF-βR, WNT posttranslational CF modification, which elucidated the possible mechanism of GA for the treatment of IPF from a novel perspective and provided a new research direction for the clinical development of new drugs against pulmonary fibrosis. Here, CFTR is linked to pulmonary fibrosis.