However, it should be noted that IL-6 blockade by tocilizumab used in case CRS is not effective in case of ICANS (Shimabukuro-Vornhagen et al., 2018a; Norelli et al., 2018; Garcia Borrega et al., 2019; Yáñez et al., 2019). This evidence concerns the gene IL6 and congenital rubella syndrome.