While the exact roles of PINK1 and Parkin in the pathogenesis of PD is still not well understood given the fact that mice lacking either PINK1 or parkin do not develop substantial PD‐relevant phenotypes, this study implies that PINK1–Parkin‐dependent mitophagy mitigates PD via fine‐tuning innate immunity response. This evidence concerns the gene PRKN and Parkinson disease.