PIM3 and neoplasm: Moreover, a significant association was observed between PIM3 expression alteration in tumor tissues and lymph node involvement (P ≤.044).The analysis of PIM3 expression at different stages (S1-S4) showed that PIM3 expression increased significantly at early stage I (P≤0.001) and no significant expression was found in the S2, S3, and S4 stages (Figure 4).