In this study, although PIM3 expression was generally not considerably different between tumor and normal adjacent tissues, but it was found that PIM3 was significantly expressed at early stage I. Regarding the aberrant expression of PIM3 and its function as a proto-oncogene in various cancers, it seems that in CRC, PIM3 has stage-dependent expression and in stage I of CRC, PIM3 acts as a proto-oncogene, helping tumor formation. The gene discussed is PIM3; the disease is cancer.