According to subgroup analysis based on cancer type, there was a significant association between HIF-1α expression and poor OS in GC (HR=2.156, 95% CI: 1.352-3.438, p<0.000), CRC (HR=1.874, 95% CI: 1.545-2.273, p<0.001), and EsoC (HR=1.645, 95% CI: 1.150-2.353, p=0.024); however, no significant association was seen regarding the HCC (HR=1.783, 95% CI: 0.968-3.282, p=0.063) (Figure 2). The gene discussed is HIF1A; the disease is cancer.