HIF1A and hepatocellular carcinoma: Different studies have indicated the significant connection between high level expression of HIF-1α and poor OS and DSF in patients with digestive system malignancies such as esophageal cancer (EsoC) (12-14), colorectal cancer (CRC) (14-16), gastric cancer (GC) (17-19), pancreatic adenocarcinoma (PDAC) (20), and hepatocellular carcinoma (HCC) (10, 21, 22).