COMP levels were not significantly different according to the Child-Pugh classification of severity of liver disease in cirrhotic and HCC patients (KW= -0.650 & MW= 0.391, respectively, and p˃0.05), while it was significantly increased in the BCLC stage (D) when compared with other stages (F=11.143, p<0.001). The gene discussed is COMP; the disease is hepatocellular carcinoma.