A 60‐year‐old woman previously diagnosed with acute myeloid leukaemia (AML) with fibrosis (normal karyotype, NPM1‐mutated, FLT3‐ITD negative, TET2 mutations (two variants) and SRSF2 mutations detected on our myeloid gene panel) presented with worsening pain and swelling in her right arm and leg. This evidence concerns the gene NPM1 and acute myeloid leukemia.