Forty‐one patients harbored the common SPTA1 mutation c.6531‐12C > T (α‐spectrinLELY), which is considered benign in itself but may cause overt HS, hereditary elliptocytosis or hereditary pyropoikilocytosis in trans to SPTA1 mutations [42, 43]. The gene discussed is SPTA1; the disease is Pyropoikilocytosis.