NFKB1 and inflammatory response: In vascular inflammation, inflammatory stimuli trigger the upregulated expression of BRINP3 through the NF-κB and JNK signaling pathways, and BRINP3 increases the mRNAs of leukocyte adhesion molecules through the ROS–NF-κB signaling pathway, thus enhancing monocyte adhesion to endothelial cells [24].