PRKG1 and colonic neoplasm: As the second messenger of intracellular information transmission, the cyclic guanosine monophosphate- (cGMP-) related signal pathway plays an important role in the treatment of colon [44]; the cGMP-PKG dimer and related pathways formed by cGMP-dependent protein kinase G (PKG) enhance the role of the original cGMP-monomer as a second messenger for intracellular communication, which plays an important role in inhibiting the progression of colon cancer [45, 46].