In the development of colon cancer, tumor-derived exosomes can mediate this process through a variety of ways, such as targeting thioesterase superfamily member 4- (THEM4-) mediated PI3K/AKT and NF-κB pathways [16], targeting programmed cell death protein 4 (PDCD4) [17]. The gene discussed is THEM4; the disease is malignant colon neoplasm.