We have constructed a potential miRNA-mRNA regulatory network, and several candidate targets were identified to be effectively (hsa-miR-623, has-miR-320C, has-miR-486-5p, has-miR-1290, NUPL2, RANBP1, SRPX2, STAU1, PGRMC2, CADM1, and GNAI1) involved in the pathogenesis of colon cancer, which provides a new direction and potential therapeutic targets for colon cancer research. Here, SRPX2 is linked to malignant colon neoplasm.