miR-182 is highly expressed in exosomes derived from gallbladder cancer, which can increase the expression level of N-cadherin and MMP2 by targeted inhibition of reversion-inducing-cysteine-rich protein with kazal motifs (RECK) and, finally, significantly promote the metastasis and invasion of gallbladder cancer cells [27]. This evidence concerns the gene CDH2 and gallbladder cancer.