Nine of these genes (NLRP2, TP63, CYCS, CASP9, IL1A, CHMP2B, CHMP4C, CHMP3, and IL1B) were downregulated, while 32 genes (HMGB1, CHMP4B, IRF2, CHMP2A, CHMP6, TP53, GPX4, CASP3, PLCG1, NOD1, GSDMD, CASP8, IL18, CHMP4A, IRF1, BAX, NLRP1, CASP4, NLRP3, GSDMA, NLRP6, CASP1, NLRC4, GSDMB, PYCARD, GSDMC, NLRP7, NOD2, GZMB, CASP5, AIM2, and GZMA) were upregulated in cancer tissues. The gene discussed is GZMB; the disease is cancer.