The consequences indicated there were seven prognostic genes with high expression negatively relevant to surviving rate of ccRCC sick persons (CASP3, CASP4, CASP5, AIM2, CASP9, GSDMB, and PYCARD), and two prognostic genes with high expression positively correlated with surviving rate of ccRCC sick persons (CHMP3 and CHMP4C), P < 0.05. The gene discussed is CASP5; the disease is nonpapillary renal cell carcinoma.