Our previous study demonstrated that triggering receptors expressed on myeloid cells-1 (TREM-1) and dendritic cell-associated C-type lectin-1 (Dectin-1), the vital pattern recognition receptors (PRRs) in the innate immune response, initiated the whole anti-infection process, positively participated in the pathogenesis of ocular fungal infection, and provided the foundation of the adaptive immune response [2–4]. The gene discussed is CLEC7A; the disease is infection.